PurposeAlthough an increasing body of literature suggests a relationship between brain irradiation and deterioration of neurocognitive function, it remains as the standard therapeutic and prophylactic modality in patients with brain tumors. This review was aimed to abstract and evaluate the prediction models for radiation-induced neurocognitive decline in patients with primary or secondary brain tumors.MethodsMEDLINE was searched on October 31, 2021 for publications containing relevant truncation and MeSH terms related to “radiotherapy,” “brain,” “prediction model,” and “neurocognitive impairments.” Risk of bias was (...) assessed using the Prediction model Risk Of Bias ASsessment Tool.ResultsOf 3,580 studies reviewed, 23 prediction models were identified. Age, tumor location, education level, baseline neurocognitive score, and radiation dose to the hippocampus were the most common predictors in the models. The Hopkins verbal learning and the trail making tests were the most frequent outcome assessment tools. All studies used regression as machine learning method. All models were judged to have a high risk of bias mainly due to issues in the analysis.ConclusionExisting models have limited quality and are at high risk of bias. Following recommendations are outlined in this review to improve future models: developing cognitive assessment instruments taking into account the peculiar traits of the different brain tumors and radiation modalities; adherence to model development and validation guidelines; careful choice of candidate predictors according to the literature and domain expert consensus; and considering radiation dose to brain substructures as they can provide important information on specific neurocognitive impairments. (shrink)

Few thinkers have left such an influence across such a diverse range of studies as Michel Foucault has. This book pays homage to that diversity by presenting a multidisciplinary series of analyses dedicated to the question of power today.

This report is an attempt to reread the event of Revelation in view of DV 8: «Ecclesia, volventibus saeculis, ad plenitudinem divinae veritatis iugiter tendit, donec in ipsa consummentur verba Dei». The text aims at clarifying the eschatological character of Revelation, raising however a theological problem of great importance: if and in what measure is it possible to think of Revelation as a never concluded process, if the theological tradition asserts that Revelation is concluded with the death of the last (...) Apostle and Dei Verbum speaks of Christ as the fullness of Revelation? The eschatological character of Revelation is investigated in the light of the dynamism of the Tradition, in particular of DV 8, which gives indications of great interest to resolve the matter of the persistence of Revelation in the time of the Church. The report affirms that the Tradition does not limit itself to the understanding of the revealed fact, but it points out the participation of the Church in the dynamism of Revelation itself. The conclusion is reached by means of a description of the constitutive relationship between Christian experience and knowledge - described in Dei Verbum as intima spiritualium rerum quam experiuntur intelligentia - which has it most clear and most pertinent expression in the sensus fidei. (shrink)

My essay aims to demonstrate that Neoliberalism exercises its art of government on forms of life turning their potentiality into adaptability. According with one of most influential reference thinker of Neoliberalism, Friedrich von Hayek, the spontaneous order of the market requests the constant adaptation of individuals to circumstances of which no one can be aware and can master. However, such adaptability – that could come from a certain negative philosophical anthropology – is the reverse side of the same potentiality theorized (...) by authors of Italian Thought like Agamben, Esposito and exponents of Post-Operaism. The paper aims to focus the condition for which such conversion of potentiality into adaptability is prevented. (shrink)

_Riassunto_: Diversi studi hanno posto in risalto le affinità tra la filosofia critica di Wittgenstein e la psicoanalisi di Lacan. Questo lavoro passa in rassegna alcuni aspetti comuni ai due autori, delineando una prospettiva d’incontro teoretica e concettuale. Un punto d’incontro tra questi due pensatori comprende la fondamentale attenzione per il linguaggio e un atteggiamento critico verso la concettualizzazione classica della soggettività. Questo saggio tenta di sviluppare teoreticamente questi punti di contatto introducendo il concetto di soggettività senza interiorità, un soggetto (...) senza psicologia. In effetti, l’affidamento di Wittgenstein sulla grammatica e il ricorso di Lacan al significante portano allo stesso risultato: considerare il linguaggio in sé come matrice della soggettività. Da questa prospettiva la fondazione della soggettività non risiede più in una certa supposta sostanza metafisica bensì in una esteriorità radicale, nei giochi linguistici. _Parole chiave_: Wittgenstein; Lacan; Inconscio; Linguaggio; Grammatica _A subjectivity without interiority: Wittgenstein with Lacan_ _Abstract_: Several studies highlight affinities between Wittgenstein’s critical philosophy and Lacan’s psychoanalysis. The following article revisits certain points of both authors, proposing a theoretical and conceptual encounter between them. Indeed, the common ground between these two thinkers includes a fundamental focus on language and a critical approach to classic conceptualisation of subjectivity. This contribution attempts to theoretically developing this encounter by introducing the concept of subjectivity without interiority, a subject without psychology. In fact, Wittgenstein’s reliance on grammar and Lacan’s use of the signifier yield the same result: pointing to language itself as the matrix of subjectivity. From this perspective, the foundation of subjectivity no longer resides in some supposed metaphysical substance, but rather in a radical exteriority, in linguistic games. _Keywords_: Wittgenstein; Lacan; Unconscious; Language; Grammar. (shrink)

Fino a una quindicina di anni fa, l’idea di una connessione forte tra l’estetica da una parte e l’intermedialità e l’interattività dall’altra non sarebbe stata probabilmente pensata nei termini in cui essa emerge nei contributi qui presentati. Di interattività si sarebbe presumibilmente parlato a partire dagli esperimenti di arte interattiva e di incontro tra arte e video: una forma di interazione tutta compresa all’interno di un discorso sulle pratiche artistiche, poco o nulla aperto al conf...

Il saggio propone una lettura estetica del documentario contemporaneo, considerato dal punto di vista delle pratiche intermediali.

Mendicanti di senso, costretti a scegliere tra l'assurdo e la speranza -- Ludwig Wittgenstein : delimitare il "dicibile" per proteggere l'"ineffabile" -- Immanuel Kant : "Ho limitato il sapere per fare spazio alla fede" -- Blaise Pascal : "È bene sentirsi stanchi e affaticati dell'inutile ricerca del vero bene, al fine di tendere le braccia al liberatore" -- Søren Kierkegaard : "Elimina la coscienza angosciata e tu puoi chiudere tutte le chiese e farne sale da ballo" -- Appendice : Tommaso (...) d'Aquino : la "mistica" di un "metafisico.". (shrink)

The essay reconsiders Wolfgang Iser’s phenomenology of reading, taken as a possible non reductionist answer to the neuroscientific theories of literature. By emphasizing the aesthetic nature of reading, thanks also to Hans Robert Jauss’ contribution, the idea of a ‘reader’s imagination’ emerges here, as a specific and unique power which allows not only the access to the world of the literary text, but opens also new spheres for the understanding and exploration of the real world. In shorts, it is concerned (...) with the constitution of a special cognitive-emotional pattern, which depends on the building of what Iser considers as the reader’s «artificial habitats», through the interaction with the text. (shrink)

Nel caso di riedizione di opera ormai classica, normalmente le ragioni che hanno spinto l’autore a riproporne o rivederne l’impianto sono proposte nella nuova prefazione o in introduzione: non è facile, invece, imbattersi – anche all’interno del corpo del testo vero e proprio - nella esplicita confessione del travaglio teorico all’origine del ripensamento, della rielaborazione e della revi­sione delle proprie posizioni interpretative. È quello che accade affrontando la lettura della recente t...